The relationship between ventilatory function and cognitive and behavioral impairment in ALS

Objective: To study the association between ventilatory function and cognitive behavioral impairment in ALS patients accounting for effects of pertinent covariates. Methods: Four hundred eighty-one were identified from Mayo Clinic Florida registry who had concurrent forced vital capacity (FVC) testing using Cognitive Behavioral Screen (ALS-CBS). Multiple linear regression analysis was used to FVC relevant covariates on ALS-CBS cognition score, subscores, caregiver inventory. Results: positively correlated subscores (p < 0.001), correlation independent site onset, age, years education. Conclusion: may be adversely affected by ALS. The presence warrants a detailed assessment function.